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The Spread Of The Virus Or The Severity Of The Disease It Causes. World Health Organization Defined. The variant is a variant of concern when the mutation causes a significant change in the behavior of . Variants of Worried Viruses Are Viruses. Variants of Concern Are Classified as Variants of Concern When They Begin to Circulate Widely With . Causes More Serious Cases or Reduces the Effectiveness of Public Health Measures.